Methotrexate is used to treat psoriasis and rheumatoid arthritis. This medication works by decreasing the pain and swelling and improves the immune system. The common side effects Loss of appetite, Indigestion, Abdominal pain, Increased liver enzymes, and vomiting. Take the medicine once a week at the same time and drink lots of fluid to stay hydrated. The doctor may perform regular check-ups and blood tests to monitor the treatment response. Methotrexate cost varies depending on the different brands in the market. It is estimated to cost around MRP ₹ 50 to ₹ 300 for strips of 10 tablets.